A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats
نویسندگان
چکیده
منابع مشابه
Oxygen-linked binding of halothane to human adult haemoglobin.
The affinity for oxygen of normal human haemoglobin (Hb) solutions was measured in the presence of increasing concentrations of halothane. We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule. The effect of halothane on P50 was independent of pH b...
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We have studied the use of ultrapurified polymerized bovine haemoglobin (HBOC-201) in patients undergoing preoperative haemodilution before liver resection. After autologous blood donation of 1 litre, 12 patients (six males, six females, mean age 59 (35-69) yr) received Ringer's lactate solution 2 litre and, in a random design, 6% hydroxyethyl starch 70,000/0.5 (HES) 3 ml kg-1 or HBOC-201 0.4 g...
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Background and Objective: Sepsis is a syndrome involving physiological, pathological, and biochemical abnormalities caused by infection. Very few studies have been performed to evaluate the prognostic value of the neutrophil-to-albumin ratio. The present study aimed to evaluate the neutrophil-to-albumin ratio in patients with sepsis admitted to the intensive care unit (ICU). Materials and Meth...
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The effects of resuscitation fluids on the brain have been investigated in previous studies by global measurements of cerebral blood flow and metabolism. In this study we have examined the effects of a novel haemoglobin-based oxygen carrier on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) after resuscitation from a volume-controlled haemorrhage of 30 min (3.0 ml...
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Systemic infections are one of commonest causes of neonatal deaths. Despite specific treatment with antibiotics, severe sepsis has a high case fatality rate [1]. Adjuvant therapies like intravenous immunoglobulins and granulocyte colony stimulating factors have been ineffective in improving the outcome [2, 3]. In such a scenario, clinicians often try drastic but unproven measures to save a rapi...
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ژورنال
عنوان ژورنال: Artificial Cells, Nanomedicine, and Biotechnology
سال: 2019
ISSN: 2169-1401,2169-141X
DOI: 10.1080/21691401.2019.1602049